Neonatal jaundice

• May develop kernicterus (possible permanent brain damage).

• More common in Mediterranean and Chinese variants. Laboratory investigation

• In steady state (i.e. no haemolysis) the RBCs appear normal.

• Heinz bodies in drug-induced haemolysis (methyl violet stain).

• Spherocytes and RBC fragments on blood film if severe haemolysis.

• 4 reticulocytes.

• 4 unconjugated bilirubin, LDH and urinary urobilinogen.

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