• Aim to reduce iron stores to <50jg/L and prevent complications of overload.

• Achieved by regular venesection (500mL blood) on weekly basis until iron deficiency develops (may take many months).

• Hb should be measured prior to each venesection and response to therapy can be monitored by intermittent measurement of the serum ferritin.

• Once iron deficiency develops a maintenance regimen can be commenced with venesection every 3-4 months.

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