Management

Treat underlying condition. Most patients with a platelet count >30 x 109/L require no specific therapy. Avoid aspirin. In the event of life-threatening haemorrhage platelet transfusion should be administered to throm-bocytopenic patients with the exception of those with heparin-induced thrombocytopenia and TTP.

Failure of production

Increased consumption

Drugs & chemicals (p392)

ITP (p388)

Viral infection

Drugs (p392)

Radiation

DIC (p512)

Aplastic anaemia (p122)

Infection

Leukaemia

Massive haemorrhage & transfusion (p524)

Marrow infiltration (p120, 634)

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