Lymphopenia (<1.5 x 109/L) may be seen in acute infections, cardiac failure, pancreatitis, tuberculosis, uraemia, lymphoma, carcinoma, SLE and other collagen disease, corticosteroid therapy, radiation, chemotherapy and anti-lymphocyte globulin. Most common cause of chronic severe lymphopenia in recent years has been HIV infection (ffl p414).

lg Chronic severe lymphopenia (<0.5 x 109/L) is associated both with opportunistic infections notably Candida species, Pneumocystis carinii, CMV, Herpes zoster, Mycoplasma spp., Cryptosporidium and toxoplasmosis and with an increased incidence of neoplasia particularly NHL, Kaposi's sarcoma and skin and gastric carcinoma.

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