Lupus anticoagulant

The paradoxically named lupus anticoagulant (LA) is arguably the commonest coagulation abnormality predisposing to thrombosis. It is something of a misnomer as it increases the risk of thrombosis not bleeding. It is an IgG /IgM autoantibody and prolongs phospholipid dependent coagulation tests (hence the use of the term anticoagulant); bleeding is very rare despite the prolonged APTT. The LA and other antiphospholipid antibodies (APL) are found in association with arterial or venous thrombosis and/or recurrent fetal loss, the 'antiphospholipid syndrome', first described by Hughes in 1988.

0 0

Post a comment