Laboratory findings

• Hb and platelets usually normal; chronic neutropenia and mild anaemia may be present.

• Mild/moderate lymphocytosis (usually <10 x 109/L); large cells with abundant cytoplasm and distinct granules.

• Most type as 'cytotoxic' T cells (CD3+ CD8+ CD16+ CD56- CD57+); others as NK cells (CD3- CD8- CD16+ CD56+ CD57+/-).

• Clonal rearrangement of T-cell receptor genes in T-LGLL.

• Polyclonal hypergammaglobulinaemia, rheumatoid factor and antinuclear antibodies occur in 50% even without joint disease.

• Bone marrow involvement is often subtle; may be diffuse or nodular pattern usually non-paratrabecular.

• No characteristic cytogenetic pattern.

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