Laboratory features

• Normochromic normocytic anaemia common.

• Leucoerythroblastic film if extensive BM infiltration ± pancytopenia.

• Hypersplenism (occasionally).

• PB may show lymphoma cells in some patients: moderate lymphocy-tosis in MCL; cleaved 'buttock' cells in FL and blasts in high grade disease.

• LFTs abnormal in hepatic infiltration.

• Serum LDH and |32-microglobulin are useful prognostic factors

• Lymph node biopsy provides the best material for classification and precise diagnosis using morphology, immunophenotype and genetic features e.g. translocations or immunoglobulin and T-cell receptor gene rearrangement.

• ~20% of patients with SLL or FL have a serum paraprotein, usually IgM.

0 0

Post a comment