Laboratory diagnosis

• Isolated thrombocytopenia; blood count otherwise normal.

• Marrow shows abundant megakaryocytes and is otherwise normal (not necessary to investigate unless clinical course or presenting features unusual).

• Platelet antibody studies difficult to perform and not necessary in most cases since they do not alter management.

• Exclude EBV infection (infectious mononucleosis).

• Exclude multisystem autoimmune disease (ACL, ANA, positive DAT test)—not necessary unless disease becomes chronic.

• Exclude underlying immunodeficiency syndrome (HIV, Wiskott-Aldrich).

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