Investigation

• FBC generally shows only modest 4 Hct.

• Further investigations should be undertaken as appropriate for persis-248 tent erythrocytosis but, by definition, fail to reveal any other abnormality.

• RCM studies demonstrates normal RCM and 5 plasma volume in ~33%; most have high normal RCM and low normal plasma volume.

• Important to exclude renal disease and arterial hypoxaemia.

• Bone marrow biopsy is not usually necessary but is normal when carried out.

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