• Streptococcus pneumoniae.

• Neisseria menigitidis.

• Haemophilusinfluenzae type B.

• Falciparum malaria.

The risk of hyposplenic infection is greatest in children in the first 6 years of life. It dwindles thereafter but the risk continues into adult life. All facing splenectomy should be vaccinated against HIB and pneumococcus, and all splenectomised children and young adults (and those with sickle cell disease) should probably take prophylactic penicillin 250-500mg daily.

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