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idarubicin 626 ileal disease 60 immunodeficiency 408-19 acquired 412-13 common variable 411 congenital syndromes 408-11 disorders, combined 408 HIV infection and AIDS 414-16,

418-19 severe combined 408, 409 immunoglobulin 169, 425 A deficiency 410 intravenous 389, 656-7 see also under myeloma immunology 302, 512, 544, 689 immunophenotyping 636-7 immunosuppression 231, 389 infant samples 424 infection 277, 512 congenital 438 post-natal 438 sickling disorders 72 transplantation 295 inherited conditions 114 innocent bystander mechanism 108 insect bites 97 intensive therapy 201-2 interferon 179-80

-a 202, 244, 252, 279 International Prognostic Scoring

System 226, 232 ipritumomab 203 iron chelation therapy 230 deficiency 34, 51, 495 deficiency anaemia 56-8 intravenous 58 overload 128-9 parenteral 58

physiology and metabolism 56 status evaluation 129 irradiation, total body 279 irritants 578

isolation procedures 550

jaundice, neonatal 103 Jehovah's Witnesses 660-1

Job's syndrome 465

joints 4, 344

disease and anaemia 50-1

Karnofsky Performance status 678 Kawasaki disease 495 kernicterus 440 Kleihauer test 633-4 Kostmann's syndrome 459

Langerhans cell histiocytosis 490-1 large cell anaplastic type 479, 480 lazy leucocyte syndrome 464-5 lead poisoning 96, 496 leishmaniasis 495 leucapheresis 586 leucocytosis due to blasts 14 leucostasis 528 leukaemia 150-90, 380, 470 acute, investigation of 544 acute myeloid 576

-Allo and autografts 310 adult T-cell leukaemia-lymphoma

(ATLL) 188-9 adult-type chronic myeloid (granulocytic) 487-8 atypical chronic myeloid 235 biphenotypic 153 cell markers in chronic lymphoproliferative disorders 174 childhood acute myeloid 482-4 childhood lymphoblastic 474-6 chronic 486-8 eosinophilic 238 myeloid (CML) 164-7 myelomonocytic (CMML) 220,

228,234-5 neutrophilic 238 hairy cell and variant 178-80 juvenile chronic myelomonocytic 487

juvenile myelomonocytic 235 large granular lymphocyte (LGLL) 186 -7

mantle cell lymphoma (MCL) 184 -5

plasma cell 32, 281 prolymphocytic 176-7 Sezary syndrome 190 splenic lymphoma with villous lymphocytes (SLVL) 182 see also acute lymphoblastic; acute myeloblastic; chronic lymphocytic Leukaemia Research Fund 666 leukaemoid reaction 14, 134 lineage infidelity 153 lipid formulation amphotericin products 331 lipoproteinaemia 114 liposomal amphotericin 330-1 liver 324

abnormality 69 biopsy 365 disease 97, 364-5 disease and anaemia 54 failure 379 locomotor problems 73 lung 556

lupus anticoagulant 400 lymph node biopsy 169 enlargement 4 lymphadenopathy 8-9 lymphocytosis 15, 138 lymphoma 194-214, 336, 470

adult T-cell leukaemia-lymphoma

188 -9 aggressive 203

anaplastic large cell 198, 199 angio-immunoblastic lymphadenopathy 198 Burkitt's 198, 199, 478, 480 central nervous system 206 childhood 478-80 diffuse large B-cell 197, 199, 478, 480

follicular 196-7, 199 indolent 202

lymphoblastic 198-9, 204 lymphoplasmacytic 197 mantle cell 184-5, 198, 199, 204 marginal zone 197, 199, 203 mature (peripheral) T-cell 197, 199, 478

mediastinal large B-cell 198 mycosis fungoides 197-8 non-endemic Burkitt 204

precursor B-lymphoblastic 199, 478, 480

precursor T-lymphoblastic 199, 478, 480

small lymphocytic 197, 199 splenic with villous lymphocytes

(SLVL) 182 T-cell rich B-cell 197 see also Hodgkin's disease; non-Hodgkin's lymphopenia 17-18, 138 lymphoproliferative disorders 174, 582

McLeod phenotype 114 macrophages 411, 413

functional disorders 491-2 maintenance therapy 243 malabsorptive disorders 61 malaria 69, 96 marrow 496

failure syndromes, rare congenital

458-60 infiltration 120, 634 manipulation of 317 stimulation 120, 634 underactivity (hypoplasia) 634-5 see also bone marrow mast cell disease (mastocytosis) 260-2,

494 maternal blood 440 samples 424 maximum surgical blood ordering schedule 646 Medical Research Council 669 melphalan 279, 610, 612, 620 and prednisolone (M&P) 278 menorrhagia 350 menstrual loss 56 metabolic problems 585 methaemoglobinaemia 110 methylprednisolone 325, 608, 622 mitoxantrone 618 mitozantrone 618 monoclonal antibodies 202-3, 204,

637 701

monoclonal gammopathy of undetermined significance 32, 268-9 monocytes 411 monocytopenia 144 monocytosis 144 mononucleosis syndromes 146 monosomy 7 syndrome 487 MOPP (chlormethine (mustine), vincristine, procarbazine, prednisolone) 600 ABVD adriamycin (doxorubicin), bleomycin, vinblastine, dacarbazine) 602 mouth care 550 mustine 600, 602 mycobacteria, atypical 557 mycoplasma 556

myeloablative conditioning regimen

612-13 myelodysplasia 218-35, 380 classification systems 220-2 clinical features 224-5 clinical variants 228 management 230-2 and myeloproliferative diseases

234-5 prognostic factors 226 syndromes 218, 228, 486-8 myelofibrosis, idiopathic 256-8 myeloma 32, 306, 336

asymptomatic (smouldering) 270-1 -autografts 310 immunoglobulin D 281 immunoglobulin E 281 immunoglobulin M 281 multiple 272-80

clinical features and presentation 272-4

combination chemotherapy 278 cytogenetics 274-5 disease progression 280 end-organ damage 274 epidemiology 272 high dose therapy and stem cell transplantation 279-80 management 277-8 melphalan and prednisolone 278 pathophysiology 272 radiotherapy 279 risk groups 277 staging systems 276-7

non-secretory 281

-related organ/tissue impairment

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