MCV useful for initial anaemia evaluation

5 MCV (<76fL)

Fe deficiency a & b thalassaemia, HbE, HbC Anaemia of chronic disorders

Normal MCV (78-98fL)

Recent bleeding Anaemia of chronic disorders Most non-haematinic deficiency causes Combined Fe + Bi2/folate deficiency

4 MCV (>100fL)

Folate or B12 deficiency Haemolytic anaemia Liver disease

Marrow dysplasia & failure syndromes including aplastic anaemia

2° to antimetabolite drug therapy e.g. hydroxyurea

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