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haemostasis, neonatal 446-7 histiocytic syndromes 490-2 hyperbilirubinaemia 444-5 leukaemia, childhood acute myeloid 482-4

leukaemia, chronic 486-8 lymphoblastic leukaemia, childhood 474-6

lymphomas, childhood 478-80 marrow failure syndromes, rare congenital 458-60 myelodysplastic syndromes, childhood 486-8 neutropenia in childhood 462-3 neutrophil function disorders 464-5

polycythaemia in newborn and childhood 428-9 red cell aplasia, acquired 454-5 red cell aplasia, congenital 452-3 red cell defects, acquired 438-9 red cell defects, congenital 436-7 red cell transfusion and blood component therapy 424-6 systemic disease in children, haematological effects of 494-6

thrombocytopenic purpura, childhood immune (idiopathic) 466-7 paediatric normal ranges 690 pain control 277 pain management 538-9 paraparesis 526 paraprotein, serum or urine 32 paraproteinaemias 266-91

amyloidosis (primary systemic)

288-91 heavy chain disease 288 monoclonal gammopathy of undetermined significance 268-9

myeloma, asymptomatic

(smouldering) 270-1 myeloma, variant forms of 281-3

paraproteinemias (continued) Waldenstrom's macroglobulinaemia 284-7 see also myeloma, multiple parathyroid disorders 48 paroxysmal nocturnal haemoglobinuria 69 parvovirus B19 infection 454, 494-5 peripheral blood stem cell transplant

302-3 perianal infection 556 periodontal infection 556 pharmacological problems 585 phenothiazines 574 phone numbers, useful 664-9 physical examination 4 pituitary disorders 48 plasma exchange (plasmapheresis) 286,

584-5 viscosity 30, 632 see also fresh frozen plasma plasmacytoma 32

plasmapheresis see plasma exchange platelet 422-3, 426 abnormal 378 activation 512 adhesion 370 aggregation 370 count 370 abnormal 346 elevated 20 in pregnancy 36 reduced 22-3 cytomegalovirus negative 650 decreased bone marrow production of 384

decreased production 386 destruction 384 dilutional loss 384 disorders, hereditary 372-3 dysfunction 378, 524 exhaustion 378, 379-80 function, acquired disorders of

378-80 function analysis-100, 371 function tests 370-1 irradiated 650 low 69

numerical abnormalities of see thrombocytopenia; thrombocytosis production failure 562-3 reactions and refractoriness 548-9 release 371

storage and administration 546-7 transfusion 230, 316, 317, 524-5, 547

Pneumocystis carinii pneumonia 556-7 POEMS syndrome 281-2 poisons 496 polycythaemia 510

in newborn and childhood 428-9 primary proliferative (rubra vera) 11

spurious 11 vera 240-4 post-transplant vaccination programme 336-7 pre-deposit system 658 prednisolone 388-9, 594, 598, 600,

602, 604 pre-extravasation syndrome 578 pregnancy 253, 350, 512 anaemia 34 anticoagulation 404-5 idiopathic thrombocytopenic purpura 392 thrombocytopenia 36 thromboembolism 405 thrombophilia 396 prematurity and anaemia 432 pre-transfusion testing 424 primary immune deficiency syndromes 411 procarbazine 598, 600, 602 procedures see protocols and procedures prophylaxis 355 anti-D 390, 441 antibacterial 550 antibiotics 569 anticoagulation 401 antifungal 550 antiviral 550 neonatal 360 and purine analogues 558 special situations 550-1 protein C 396,398 C deficiency 397 -calorie malnutrition 495 S deficiency 397 prothrombin gene mutation 397

protocols and procedures 544-628 ABVD 596

adriamycin (doxorubicin), BCNU (carmustine), cyclophosphamide, melphalan (ABCM) 620 anticoagulation, oral 590 anticoagulation therapy - heparin 588-9

BEAM (myeloablative conditioning regimen) 610, 612-13 bone marrow examination 570-1 bone marrow failure, chronic 562-3 C-Thal-Dex 628

catheters, tunnelled central venous 568-9

chemotherapy administration 572-3

chemotherapy antiemetics 574-5 chemotherapy, intrathecal 576 chlorambucil, vinblastine, procarbazine, prednisolone (ChIVPP) 598 chlormethine (mustine), vincristine, procarbazine, prednisolone (MOPP) 600 chlormethine (mustine), vincristine, procarbazine, prednisolone/adriamycin (doxorubicin), bleomycin, vinblastine, dacarbazine (MOPP/ABVD) 602 CVP 614

cyclophosphamide, vincristine, adriamycin (doxorubicin), methylprednisolone (C-VAMP) 622 cyclophosphamide, vincristine, doxorubicin, prednisolone (CHOP) 604 dexamethasone, cisplatin, cytarabine (DHAP) 606-7 ESHAP 608-9 extravasation 578-9, 580 fludarabine and cyclophosphamide 616

fludarabine, mitoxantrone (mitozantrone), dexamethasone (FMD) 618 leucapheresis 586

leukaemia, acute, investigation of 544 needlestick injuries 592-3

neutropenia, IV antibiotics, use of

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