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Clinically important defects in lymphocyte numbers and/or function can be seen as a complication of a variety of acquired diseases. They can also be due to drugs, both those given deliberately to suppress an autoimmune process and those given primarily for other reasons. Similarly neutrophils can be reduced by a large number of acquired disorders and a long list of drugs and toxins. An acquired susceptibility to infection also arises in patients with absent or poorly functioning spleens.

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