• Other B-cell lymphoproliferative disorders: IgM monoclonal protein can be demonstrated in most B-cell lymphoproliferative disorders e.g. CLL, NHL; generally very low levels; no lymphoplasmacytic BM infiltration; hyperviscosity rare; features of other lymphoproliferative disorder e.g. phenotype.

• IgM myeloma: very rare; BM contains plasma cells (cytoplasmic IgM+, CD20-, CD138+) not lymphoplasmacytic cells; myeloma associated cytogenetic abnormalities (esp. 14q translocations) and lytic bone lesions frequent.

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