Makris, M. et ai. (1997) Emergency oral anticoagulant reversal: the relative efficacy of infusions of fresh frozen plasma and clotting factor concentrates on correction of coagulopathy. Thrombosis Haemostasis, 77 477-80.

• Prepared by slow thawing of FFP at 4-6°C. Fresh plasma taken from a single donor is snap frozen then thawed at 4°C and a cryoprecipitate forms.

• Precipitate formed is cryoprecipitate which is then stored at -30°C.

• Rich in factors VIII, XIII, fibrinogen and von Willebrand factor. Per unit (bag):

- Factor VIII and vWF ~80-100iu.

- Fibrinogen ~250mg.

- Factor XIII and fibronectin.

- Does not contain other coagulation factors.

- May contain anti-A and anti-B blood group antibodies.

• Formerly (but no longer) used for management of bleeding in factor VIII deficiency and von Willebrand's disease.

• Main clinical use for cryoprecipitate is as additional support for the clotting defects induced by massive transfusion and DIC.

• All donations are screened for HIV, HBV and HCV.

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