Indications for use

• DIC (common causes include obstetric haemorrhage, postoperative complications, following trauma, severe infection, septicaemic shock, acute blood loss—see p512).

• Liver disease and biopsy.

• Massive blood transfusion—use of prophylactic FFP (1-2 units FFP/10 units of blood) and platelets is not supported by documented clinical benefit. Give as dictated by coagulation tests.

• Isolated coagulation deficiencies where no specific concentrate is readily available.

• Treatment of thrombotic thrombocytopenia purpura/haemolytic uraemic syndrome (see p468, 530).

• Non-specific haemostatic failure in a bleeding patient e.g. following surgery, in intensive care with disturbed coagulation tests where no definite diagnosis is made.

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