Importance of HLA typing

• Matching donor/recipient pairs for renal, cardiac and marrow stem cell transplantation.

• Degree of matching more critical for stem cell than solid organ transplants.

• Sibling HLA matched stem cell transplantation is now treatment of choice for many malignancies.

640 • Unrelated donor stem cell transplants are increasingly performed but outcome is poorer due to HLA disparity. As molecular matching advances, improved accuracy will enable closer matches to be found and results should improve.

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