Immunological classification of ALL

B lineage

• Pro B-ALL: HLA-DR+,TdT+,CD19+ (5% children; 11% adults).

• Common ALL: HLA-DR+,TdT+,CD19+,CD10+ (65% children; 51% adults).

• Pre B-ALL: HLA-DR+,TdT+,CD19+,CD10±,cytoplasmic IgM+ (15% children; 10% adults).

• B-cell ALL: HLA-DR+,CD19+,CD10±,surface IgM+ (3% children; 4% adults)

T lineage

• Pre-T ALL: TdT+,cytoplasmic CD3+,CD7+ (1% children; 7% adults).

• T-cell ALL: TdT+,cytoplasmic CD3+, CD1a/2/3+,CD5+ (11% children; 17% adults).

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