Immune thrombocytopenia

These conditions are due to IgG and IgM antibodies which react with antigenic sites (usually GPIIb/IIIa in ITP, platelet alloantigens in post-transfusion purpura and neonatal isoimmune purpura) on the platelet cell membrane, may fix complement and cause accelerated platelet destruction through phagocytosis by reticuloendothelial cells in liver and spleen. A compensatory increase in bone marrow megakaryocytopoiesis usually occurs which may occasionally prevent or delay the development of severe thrombocytopenia.

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