HLA related transfusion issues

• HLA on WBC and platelets may cause immunisation in recipients of blood and platelet transfusions.

• May cause refractoriness and/or febrile reactions to platelet transfusions.

• WBC depletion of products by filtration prevents this.

• Diagnosis of refractoriness confirmed by detection of HLA or platelet specific antibodies in patient's serum.

• Platelet transfusions matched to recipient HLA type may improve increments.

0 0

Post a comment