Histology and classification

Immunological analysis has resulted in reclassification of HL in the REAL and WHO Classifications of Lymphoid Neoplasia (fflp)95) into 2 major groups:

Nodular lymphocyte-predominant HL (NLPHL): 3-8%; contains large atypical B cells and lymphocytic and histiocytic (L&H) 'popcorn' cells. These cells are CD30-, CD15-, CD20+, CD45+, CD75+, CD79a+.

'Classical' HL large mononuclear (Hodgkin's cells) or binucleate/multinuclear RS cells make up only 1-2% of the cellularity of the lymph node. These cells are CD30+ and typically CD15+, CD20-, CD45-, CD75-, CD79a-. The predominant cells are an infiltrate of lymphocytes, plasma cells, eosinophils and histiocytes containing scattered neoplastic cells and a variable degree of fibrosis.

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