Haemophilia Aspecific treatment

Mild disease

• Minor bleeds may stop without factor concentrate therapy.

• Tranexamic acid (15-25mg/kg tds oral)—useful for cuts or dental extraction. Do not use when haematuria.

• DDAVP (desmopressin) for minor surgery and bleeds that fail to settle (0.3|jg/kg SC or slow IVI/20 min); may also be given by nasal spray. 30 min later take blood sample to check response (if required); plasma level increased 3-4 fold. Reduced response with repeated exposure sometimes observed.

• Cryoprecipitate no longer recommended.

Severe disease

• Factor VIII concentrates are cornerstone of management for severe disease and life-threatening situations.

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