Four histological subtypes

Nodular sclerosing HL (NSHL): ~80%; prominent bands of fibrosis and nodular growth pattern; lacunar Hodgkin's cells; variable numbers of RS cells.

Mixed cellularity HL (MCHL): ~17%; mixed infiltrate of lymphocytes, eosinophils and histiocytes with classical RS cells.

Lymphocyte depleted HL (LDHL): rare; diffuse hypocellular infiltrate with necrosis, fibrosis and sheets of RS cells.

Lymphocyte rich classical HL (LRCHL): uncommon; diffuse predominantly lymphoid infiltrate with scanty RS cells of 'classical' phenotype.

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