Favism

• Hours/days after ingestion of fava beans (broad beans).

• Beans contain oxidants vicine and convicine— free radicals— oxidise glutathione.

• Urine becomes red or very dark.

Risk of haemolysis in G6PD deficient individuals

Definite risk Antimalarial drugs Primaquine

Pamaquine (not available in UK)

Possible risk

Aspirin (1g/d acceptable in most cases)

Chloroquine

Probenecid

Quinine & quinidine (acceptable in acute malaria)

Anaiges/c drugs

Aspirin Phenacetin Others Dapsone

Methylthioninium chloride (methylene blue) Nitrofurantoin

4-quinolones (e.g. ciprofloxacin, nalidixic acid) Sulphonamides (e.g. cotrimoxazole)

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