FAB classification

Refractory anaemia (RA): cytopenia of one peripheral blood (PB) lineage; normo- or hypercellular marrow with dysplasia >2 lineages; <1% PB 220 blasts; <5% BM blasts. 25% of patients.

Refractory anaemia with ringed sideroblasts (RARS): defined as for RA plus ringed sideroblasts account for >15% nucleated erythroid cells; 15% of patients.

Refractory anaemia with excess blasts (RAEB): cytopenia of >2 PB lineages; dysplasia of all 3 BM lineages; <5% PB blasts; 5-20% BM blasts; 35% of patients.

Refractory anaemia with excess blasts in transformation (RAEB-t):

cytopenia of >2 PB lineages; dysplasia of all 3 BM lineages; >5% PB blasts; 21-30% BM blasts or Auer rods in blasts; 15% of patients.

Chronic myelomonocytic leukaemia (CMML): PB monocytosis (>1 x 109/L); <5% PB blasts; <20% BM blasts; 10% of patients1.

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