E

electrophoresis 633 elevated 12

fetal, hereditary persistence of 93 H disease 86 Lepore 92

production, genetic control of 70-1 SC 80 SD 80 SO 80 unstable 84 haemoglobinopathy 69 haemoglobinuria March 96

paroxysmal nocturnal 124-5 haemolysis autoantibody mediated 108 drug-induced 102 due to infection and fever 102 intravascular 69 microangiopathic 34 non-immune 96-7 oxidative 96 haemolytic crises 73

disease of newborn 440-3 syndromes 68-9 uraemic syndrome 468-9 haemophagocytic syndromes 491-2 haemophilia A and B 352-5 A-specific treatment 354 B 354-5

with inhibitor 367 management 353-4 haemopoietic growth factors 306 haemorrhage, life-threatening 253, 467

haemorrhagic disease of the newborn 362-3

haemosiderin, urinary 635-6 haemostasis 690 neonatal 446-7 see also haemostasis and thrombosis haemostasis and thrombosis 344-405 anticoagulant therapy 402 anticoagulants, acquired 366-8 anticoagulation in pregnancy and post-partum 404-5 bleeding, vWF-related 348-50

coagulation disorders - clinical approach 344-5 coagulation disorders - laboratory approach 346-7 defects, multiple 358 dysfibrinogenaemia 357 factor VII 357-8 factor XI 356

factor XIII (fibrin stabilising factor) 358

fibrinogen 357 haemophilia A and B 352-5 haemorrhagic disease of the newborn 362-3 Henoch-Schonlein purpura 376 liver disease 364-5 Osler-Weber-Rendu syndrome 374 platelet disorders, hereditary 372-3 platelet function, acquired disorders of 378-80 platelet function tests 370-1 thrombocytopenia 384-5, 386,

388-9, 392-3 thrombocytosis 382 thrombophilia 394-5, 396-8, 400-1 vitamin K deficiency 360-1 von Willebrand's disease 348-50 haemostatic defects 25 Ham's test 636 hapten mechanism 108 haptoglobin 633 heavy chain disease 32, 288 Henoch-Schonlein purpura 376 heparin 402, 588-9

-induced thrombocytopenia 520-1 low molecular weight 588 overdosage 518 unfractionated 588 hepatitis B 40, 76, 353 hepatitis C 353 hereditary disorders 582 aplastic anaemia 122 haemolytic syndromes 68 neutropenia 17 hereditary persistence of fetal haemoglobin 93 high dose therapy 205, 231-2, 279, 287 high grade regimens 201 histiocytic syndromes 490-2 histiocytosis, malignant 492 histology 471 history taking 2-3

HIV infection and AIDS 353, 414-16, 418-19

Hodgkin's disease 208-14, 478 adjuvant radiotherapy 213 advanced stage 212 Ann Arbor staging classification 210 classical 208 clinical features 209 clinical imaging criteria 211 combination chemotherapy 212-13 early stage 211

histology and classification 208-9 incidence 208 initial therapy 211 investigation, diagnosis and staging 210

lymphocyte depleted 209 lymphocyte rich classical 209 mixed cellularity 209 nodular lympocyte-predominant

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