Druginduced haemolysis in G6PD deficiency

• Begins 1-3d after ingestion of drug.

• Anaemia most severe 7-10d after ingestion.

• Associated with low back and abdominal pain.

• Urine becomes dark (black sometimes).

• Red cells develop Heinz body inclusions (cleared later by spleen).

• Haemolysis is typically self-limiting.

• Implicated drugs shown in table (next page).

• But heterogeneous; variable sensitivity to drugs.

• Risk and severity are dose related.

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