Diagnostic criteria for ET

1. Persistent elevation of the platelet count >600 x 109/L.

2. Absence of identifiable cause of reactive thrombocytosis.

3. Normal red cell mass or Hct <0.40.

4. Normal BM iron stores or normal serum ferritin or normal MCV.

5. Absence of Ph chromosome and BCR-ABL fusion gene.

6. Absence of significant BM fibrosis (<33% of biopsy in absence of splenomegaly and leucoerythroblastosis.

7. Absence of cytogenetic or morphological evidence of MDS.

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