Diagnosis

• Reticulocytes are 44.

• Neutrophilia common.

- Monoclonal in NHL.

- Polyclonal in infection-related CHAD.

• IgM antibodies react best at 4°C (thermal amplitude 4-32°C).

• Specificity

- Anti-i (infectious mononucleosis)—causes little haemolysis in adults since RBCs have little anti-i (cf. newborn i >> I).

• Serum haptoglobin 5.

• Exclude underlying lymphoma (BM, blood and marrow cell markers).

• Autoimmune profile to exclude SLE or other connective tissue disorder.

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