Diagnosis Clinical features

The LA was first described in patients with SLEā€”hence its name. Other underlying disorders include the lymphoproliferative disorders, HIV, other autoimmune disorders and drugs (e.g. phenothiazines). The antiphospho-lipid syndrome (APS) is seen in patients with SLE but is often primary. Thrombosis, the major defining feature, may be arterial (stroke, ocular occlusions, Ml, limb thrombosis) or venous (DVT, PE, renal, hepatic and portal veins). Fetal loss may be as high as ~80% in women with APL.

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