Cytogenetic analysis

• Abnormalities found in BM cytogenetic analysis of 40-70% of patients with de novo MDS and 80-90% of patients with secondary MDS.

• Single or complex abnormalities at diagnosis may evolve during course of disease.

• More complex abnormalities associated with more aggressive subtypes and higher % blasts and with secondary MDS.

• Most frequent abnormalities involve chromosomes 5, 7, 8, 11, 12 and 20; most typical are 8+, 7- or 7q-, 5- or 5q-.

• Isolated 5q-, 20q- and normal karyotype favourable; complex karyotypes (>3 abnormalities), 7- or 7q- unfavourable.

0 0

Post a comment