Conditions associated with paraprotein production

Stable production

• Monoclonal gammopathy of undetermined significance (MGUS).

• Asymptomatic (smouldering) myeloma.

Progressive production

• Complete immunoglobulins: IgG, IgA, IgD, IgM, IgE.

• Free light chains (Bence Jones protein).

266 • Solitary plasmacytoma of bone (SPB).

• Extramedullary plasmacytoma (SEP).

• Waldenstrom's macroglobulinaemia (WM).

• Chronic lymphocytic leukaemia.

• Malignant lymphoma.

• Heavy chain disease.

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