Chronic arthropathy

Repeated joint bleeds preventable but older patients often have arthropathy.

Development of factor VIII inhibitors

Suggested by 5 response to concentrates; occurs in 15-25% haemophilia A patients following treatment (IX inhibitors are uncommon; <2%).

Transmission of HBV, HCV and HIV

Transmission high prior to the introduction of viral inactivation of concentrates (1985 in the UK).

HIV management

Prophylaxis against infections and retroviral inhibition have significantly improved prognosis.

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