Common protocols

1. CNS prophylaxis for ALL and high grade NHL:

- methotrexate 10mg/m2 (max 12.5mg) x 6 injections at weekly intervals.

2. CNS prophylaxis for AML:

- ara-C 30mg/m2 (max 50mg), dosage schedule varies.

3. CNS treatment for ALL:

Triple IT regimen viz:

methotrexate 15mg/m2 (max 12.5-15mg). ara-C 30mg/m2 (max 50mg). hydrocortisone 15mg/m2. Usually given twice weekly until CSF clear of blasts then weekly to a maximum of 6 total courses. Consider using folinic acid rescue.

0 0

Post a comment