Clonality assessment

Particularly useful in determining whether there is a monoclonal B cell or plasma cell population.

y Monoclonal B cells from e.g. NHL will have surface expression of k or \ light chains but not both.

y Polyclonal B cells from e.g. patient with infectious mononucleosis will have both k and \ expression.

CD13 + , CD33 + , ± CD 34, ± CD14 +ve. CD10 and TdT +ve.

CD10, CD19, surface Ig +ve. 037

CD5, CD19, CD23, weak surface Ig +ve.

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