Clinical presentation

Haemophilia A and B—clinically indistinguishable. Symptoms depend on the factor level.

Severe disease (plasma level <1%)

Usually presents in the first years of life with easy bruising and bleeding out of proportion to injury

Moderate disease (1-5% factor level)

Intermediate & variable severity

Mild disease (>5%)

May only present after trauma/surgery in later life

General features

Haemarthrosis; spontaneous bleeding into joints (knees>elbows>ankles>hips>wrists) produce local tingling, pain; later—swelling, limitation of movement, warmth, redness, severe pain

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