Clinical features
• Chronic intravascular haemolytic anaemia particularly overnight (?due to lower blood pH). Infections trigger acceleration of haemolysis.
• WBC and platelet production also often 5.
• Chronic haemolysis may induce nephropathy.
• Haemoglobinuria usually results in iron deficiency.
• 44 tendency to venous thrombosis particularly at atypical sites e.g. hepatic vein (Budd-Chiari syndrome), sagittal sinus thrombosis.
• Fatigue, dysphagia and impotence occasionally seen.
Post a comment