Clinical features

Acquired inhibitors develop in the elderly, during pregnancy, in association with autoimmune and malignant disease, various skin disorders (psoriasis, pemphigus, erythema multiforme) infections, drug therapy (penicillin, aminoglycosides, phenothiazines, etc). Symptoms include bleeding (postoperatively this can cause major problems), easy bruising—haemarthrosis is rare. The mortality is significant, as many as 25% patients with persisting VIII inhibitors will die from bleeding.

15-25% of haemophilia A patients develop inhibitors. In half, inhibitors are transient and low titre, being noted incidentally on review. In half, however, an VIII inhibitor will present a major clinical problem. Suspicion is aroused by bleeding that fails to respond to the usual doses of factor concentrate. Patients may be low (<5BU) or high (>10BU) responders; in the latter, treatment will be difficult.

How To Deal With Rosacea and Eczema

How To Deal With Rosacea and Eczema

Rosacea and Eczema are two skin conditions that are fairly commonly found throughout the world. Each of them is characterized by different features, and can be both discomfiting as well as result in undesirable appearance features. In a nutshell, theyre problems that many would want to deal with.

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