Clinical features

• Early haemorrhagic disease of the newborn presents in the first week of life with bleeding—umbilical cord, the skin, post circumcision bleeding is common; ICH is rare. Presents <24h in haemorrhagic disease of the newborn 2° to maternal drug ingestion (anti-epileptic,

• Late haemorrhagic disease of the newborn has a peak incidence at 2-6 weeks but can occur up to 6 months of age. Underlying cholestatic disease is often present, biliary atresia, cystic fibrosis, a-1 antitrypsin deficiency and diarrhoea are documented causes. About half of cases present with ICH.

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