Clinical features

• Dietary deficiency may arise within a few weeks in patients who are not eating well since body stores are limited and the t4 of the vitamin is short (days). Coagulopathy due to deficiency common in ITU patients unless vitamin K administered.

• Systemic illness, parenteral nutrition, hepatic or renal failure, hypo-albuminaemia, antibiotics (e.g. cephalosporins) are compounding factors.

• Haemorrhagic disorder of the newborn. Prematurity and maternal 360 intake of anticonvulsants increase the incidence. Usually presents in first few days of life with bleeding (e.g. umbilical stump). Cerebral haemorrhage is rare. A late form seen 3-6 months after birth is rare may be due to liver disease, intestinal malabsorption.

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