Clinical features

• Young children (<4 years) are especially prone to the disease.

• Acute onset with a history of abdominal pain and bloody diarrhoea.

• Onset of 5 urine output heralding renal failure occurs days later.

• In ~10% onset is non-epidemic and insidious—can be associated with chemotherapy/TBI.

• Other symptoms: anaemia (may be severe), jaundice, bruising, bleeding.

• Absence of fever and neurologic signs distinguish it from TTP.

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