Chronic neutrophilic leukaemia CNL

• Exclude underlying infection or neoplasia e.g. myeloma, before considering diagnosis of CNL.

• Neutrophilia without left shift, eosinophilia or basophilia.

• Modest splenomegaly common ± hepatomegaly.

• Marrow hypercellular.

• BM cytogenetics usually normal.

• Most patients asymptomatic.

• Treatment often unnecessary.

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