Causes of increased destruction of platelets

Immune

• Associated with other autoimmune states SLE, CLL, lymphoma (ffl p392).

• Drug-induced: heparin, gold, quinidine, quinine, penicillins, cimetidine, digoxin.

• Infection: HIV, other viruses, malaria.

• Post-transfusion purpura (ffl p506).

• Neonatal alloimmune thrombocytopenia (NAIT, ffl p448).

Non-immune

• Kasabach-Merritt syndrome.

• Congenital/acquired heart disease.

• Cardiopulmonary bypass (ffl p378).

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