Causes of 5 reticulocyte counts

Marrow infiltration due to

• Other malignancy.

Marrow underactivity (hypoplasia) due to

• Fe, folate or B12 deficiency. Note: return of reticulocytes is earliest sign of response to replacement therapy.

• Immediately post-chemotherapy or radiotherapy.

• Autoimmune disease especially rheumatoid arthritis.

• Malnutrition.

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