Available QoL instruments include

• Functional Living Index - Cancer (FLIC)1

• Functional Assessment of Cancer Therapy (FACT)2

• European Organisation for Research and Treatment in Cancer (EORTC) Quality of Life Questionnaire C-30 (QLQ C30)3

Data from validated QoL questionnaires are now accepted as a requirement and a clinical end point in many major clinical trials, especially in malignancies, particularly those where survival differences are minimal between contrasting therapy approaches. Where survivals are minimally affected it is then essential to focus on treatments which will offer the best QoL.

Schipper, H. et al. (1984) Measuring the quality of life of cancer patients: the Functional Living Index-Cancer: development and validation. J Clin Oncol, 2, 472-483; Cella, D.F. et al. (1993) The Functional Assessment of Cancer Therapy scale: development and validation of the general measure. J Clin Oncol, 11, 570-579; Aaronson, N.K. et al. (1993) The European Organization for Research and Treatment of Cancer QLQ-C30: a quality-of-life instrument for use in international clinical trials in oncology. J Natl Cancer Inst, 85, 365-376.

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