Aggressive lymphomas

Diffuse large B-cell lymphoma: Pan-B markers (CD20+, CD79a+), generally Ig+; Ki67 <90% favours DLBCL (cf Burkitt >99%); probably multiple unrecognised entities; two subgroups delineated by gene expression profiling using DNA microarrays: germinal centre-B-cell profile (favourable) and activated B-cell profile (unfavourable). Der(3)(q27) involving BCL-6 gene mutations 35%; t(14;18) 25%; t(8;14) 15%.

Mature T-cell lymphomas: Pan-T markers (CD3+, CD2+); TdT- (cf. precursor T-lymphoblastic TdT+).

Mantle cell lymphoma: Pan-B markers; CD5+, strong SIg, CD23-, cyclin-D1+. t(11;14)(q13;q32) in 70%.

Anaplastic large cell lymphoma: Pan-T markers, TdT-, CD30+, ALK+. t(2;5)(p23;q35) in 60%.

0 0

Post a comment