Affecting T cells

DiGeorge syndrome

Absence or hypoplasia of the thymus and parathyroid glands with aortic arch anomalies or other congenital heart defects. This congenital anomaly of the 3rd and 4th branchial arches usually presents with hypocalcaemic fits or problems with a heart defect. Total thymic aplasia occurs only in a minority, with severe immunodeficiency and a high risk of transfusion-transmitted GvHD. Most have some T-cell function, and relatively minor 410 problems with impaired immunity for which treatment is supportive.

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