• Avoids many problems associated with allogeneic blood transfusion. Disadvantages

• Patients must be 'fit' for pre-donation programme (e.g. to donate 450mL 2-4 x pre-op) and live near transfusion centre.

• Requires close coordination between surgeon, patient and transfusion lab and fixed date for surgery.

• Little/no reduction in workload—blood must be treated in same way as regular donor units (including microbiological screening, grouping, compatibility testing, etc).

• Transfusion should be to donor only.

• Bacterial contamination of blood units may still occur.

• Patient may still require additional allogeneic units.

• Blood may be wasted if operation cancelled.

• Patients with epilepsy excluded (risk of seizures).

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