Administration

• Out-patient regimen.

• Consider sperm banking in males.

• Add allopurinol 300mg/d throughout first treatment cycle.

• Antiemetic therapy for highly emetogenic regimens.

• Alcohol prohibited with procarbazine; avoid monoamine oxidase inhibitors.

• Repeat treatment if WBC >3.5 x 109/L and platelets >100 x 109/L.

• 25% dose reduction if WBC 2.5-3.5 x 109/L or platelets 75-100 x 109/L.

• Delay treatment 1 week if WBC <2.5 x 109/L or platelets <75 x 109/L.

• Treat to complete remission + 2 cycles.

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